Cephalosporin Ceph"a*lo*spor`in (s[e^]f"[.a]*l[-o]*sp[=o]r`[i^]n), n. [from Cephalosporium, a fungus producing the first of the series discovered.] (Chem.) any of a class of chemical substances, some of which have therapeutically useful antibacterial activity, whose structure contains a beta-lactam ring fused to a six-membered ring containing a sulfur and a nitrogen atom. The first of the series, {cephalosporin C}, was discovered by G. Brotzu in 1955 in the culture broth of a {Cephalosporium} species found off the coast of Sardinia. Other cephalosporins have been found to be produced by species of soil bacteria (actinomycetes). Many semisynthetic analogs have been tested for antibacterial effect, and several of them have found use as important clinically useful antibacterial agents, some of which may be taken orally for treatment of bacterial infections. The cephalosporins are the second class of beta-lactam antibiotic to be discovered, the first being the {penicillins} and more recent classes being the {thienamycins} and {sulfazecins}. The {cephamycins} are a variant of cephalosporins with a methoxyl group on the beta-lactam ring, rendering them more resistant to penicillinases. Among the cephalosporins which have been found clinically useful are {cephalexin}, {cephaloridine}, and {cephalothin}. [PJC]

The Collaborative International Dictionary of English. 2000.

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  • cephalothin sodium — [USP] the monosodium salt of cephalothin, used in the treatment of infections of the major organ and tissue systems due to sensitive pathogens; administered parenterally …   Medical dictionary

  • cephalothin — noun Etymology: cephalosporin + thi + 1 in Date: 1962 a semisynthetic broad spectrum antibiotic derived from cephalosporin and used in the form of its sodium salt C16H15N2NaO6S2 …   New Collegiate Dictionary

  • cephalothin — ceph·a·lo·thin (sĕfʹə lə thĭn) n. A semisynthetic analogue of cephalosporin having a broad spectrum of antibiotic activity that is administered parenterally and used especially to treat systemic infections caused by susceptible microorganisms.  … …   Universalium

  • cephalothin — noun A semisynthetic antibiotic related to cephalosporin …   Wiktionary

  • cephalothin — Chemically modified cephalosporin C, a broad spectrum antibiotic. * * * ceph·a·lo·thin sef ə lə (.)thin n a semisynthetic broad spectrum antibiotic C16H15N2NaO6S2 that is an analog of a cephalosporin and is effective against penicillin resistant… …   Medical dictionary

  • cephalothin — ceph·a·lo·thin …   English syllables

  • cephalothin — noun a semisynthetic analogue of cephalosporin • Hypernyms: ↑cephalosporin, ↑Mefoxin …   Useful english dictionary

  • Cephaloridine — Systematic (IUPAC) name (6R,7R) 8 oxo 3 (pyridin 1 ium 1 ylmethyl) 7 [(2 thiophen 2 ylacetyl)amino] 5 thia 1 azabicyclo[4.2.0]oct 2 ene 2 carboxylate Clinical data …   Wikipedia

  • Cephalosporin — See also: Discovery and development of cephalosporins Core structure of the cephalosporins …   Wikipedia

  • Discovery and development of cephalosporins — Cephalosporins are a broad class of bactericidal antibiotics that include the β lactam ring and share a structural similarity and mechanism of action with other β lactam antibiotics (e.g. penicillins, carbapenems and aztreonam).[1] The… …   Wikipedia

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